(Selection from the Chair of Biochemical Pharmacology , University of Konstanz)

Tiegs, G. and Wendel, A. "Leukotriene-mediated liver injury".Biochem. Pharmacol. 37, 2569-2573, 1988

Jaeschke, H. and Wendel, A. "Choleresis and increased biliary efflux of glutathione induced by phenolic antioxidants in rats". Toxicology 52, 225-235, 1988

Tiegs, G., Wolter, M. and Wendel, A. "Tumor Necrosis Factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice". Biochem. Pharmacol. 38, 627-631, 1989

Otter, R., Reiter, R. and Wendel, A. "Alterations in the protein-synthesis, -degradation and/or –secretion rates in hepatic subcellular fractions of selenium-deficient mice". Biochem. J. 258, 535-540, 1989.

Reiter, R., Otter, R. and Wendel, A. "Subcellular distribution of selenium in deficient mouse liver"
Biochem. J. 258, 541-545, 1989

Weitzel, F., Ursini, F. and Wendel, A., "Dependence of mouse liver phospholipid hydroperoxide glutathione peroxidase on dietary selenium" In: Selenium in Biology and Medicine (Wendel, A., ed.) Springer-Verlag, pp. 29-32, 1989

Reiter, R., Otter, R., Haney, H.M. and Wendel, A., "Selenium-dependent metabolic modulations in mouse liver" In: Selenium in Biology and Medicine (Wendel, A., ed.) Springer-Verlag, pp. 85-89, 1989

Ammon, H.P.T., Klumpp, S., Fuß, A., Verspohl, E.J., Jaeschke, H., Wendel, A. and Müller, P.
"A possible role of plasma glutathione in glucose-mediated insulin secretion: in vitro and in vivo studies in rats" Diabetologia 32, 797-800, 1989

Wendel, A., "The role of glutathione and its eicosanoid adducts in experimental
hepatitis in mice" In: Glutathione Centennial, Molecular Perspectives and Clinical
Implications (Taniguchi, N., Higashi, T., Sakamoto, Y., Meister, A., eds.) Academic Press, pp. 333-342, 1989

Wang, J. and Wendel, A. "Studies on the hepatotoxicity of galactosamine/endotoxin or galactosamine/TNF in the perfused mouse liver" Biochem. Pharmacol. 39, 267-270, 1990

Wendel, A. "Biochemical pharmacology of inflammatory liver injury in mice"
In: Methods in Enzymology 186, 675-680, 1990

Uhlig, S. and Wendel, A. "Glutathione enhancement in various mouse organs and protection by
glutathione isopropyl ester against liver injury" Biochem. Pharmacol. 39, 1877-1881, 1990

Werner, C. and Wendel, A. "Hepatic uptake and antihepatotoxic properties of Vitamin E and
liposomes in the mouse" Chem.-Biol. Interactions 75, 83-92, 1990

Wendel, A., Tiegs, G. and Werner, C. "Manipulation of liver glutathione status - A double-edged sword" In: Glutathione: Metabolism and Physiological Functions (Vina, J., ed.) CRC Press, pp. 21-28, 1990

Tiegs, G., Niehörster, M. and Wendel, A., "Leukocyte alterations do not account for hepatitis induced by endotoxin in TNF* in galactosamine-sensitized mice" Biochem. Pharmacol. 40, 1317-1322, 1990

Niehörster, M., Tiegs, G., Schade, U.F. and Wendel, A. "In vivo evidence for protease-catalysed mechanism providing bioactive tumor necrosis factor *". Biochem. Pharmacol. 40, 1601-1603, 1990

Weitzel, F., Ursini, F. and Wendel, A. "Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion" Biochim.et Biophys. Acta 1036, 88-94, 1990

Flohé, S., Heinrich, P.C., Schneider, J., Wendel, A. and Flohé, L. "Time course of IL-6 and TNF* release during endotoxin-induced endotoxin tolerance in rats". Biochem. Pharmacol. 41, 1607-1614, 1991

Hartung, T. and Wendel, A. "Endotoxin-inducible cytotoxicity in liver cell cultures - I" Biochem. Pharmacol. 42, 1129-1135, 1991

Hartung, T., Leist, M., Tiegs, G., Baschong, W. and Wendel, A. "Solcoseryl prevents inflammatory and hypoxic but not toxic liver damage in rodents",Inflammopharmacology 1, 49-60, 1991

Ruffmann, R. and Wendel, A., "GSH rescue by N-acetylcysteine".Klin. Wochenschr. 69, 857-862, 1991

Wendel, A., "Reactive oxygen species, antiproteases, and cytokines in sepsis", Klin. Wochenschr. 69, 969-974, 1991

Jaeschke, H., Kleinwaechter, C. and Wendel, A. "NADH-dependent reductive stress and ferritin-bound iron in allylalcohol-induced lipid peroxidation in vivo: The protective effect of vitamin E"
Chemico-Biol. Interactions 81, 57-68, 1992

Niehörster, M., Schönharting, M. and Wendel, A. "A novel xanthine derivative counteracting in vivo tumor necrosis factor * toxicity in mice".Circulatory Shock 37, 270-273, 1992

Niehörster, M. and Wendel, A. "A link between reactive oxygen and LPS-induced release of TNF*
in vivo".Biochem. Pharmacol. 43, 1151-1154, 1992

Tiegs, G., Hentschel, J. and Wendel, A."A T-cell dependent experimental liver injury in mice inducible by Concanavalin A" J. Clin. Invest. 90, 196-203, 1992

Tiegs, G., Freudenberg, M.A., Galanos, C. and Wendel, A."Colchicine prevents TNF-induced toxicity in vivo" Infect. Immun. 60, 1941-1945, 1992

Görgen, I., Hartung, T., Leist, M., Niehörster, M., Tiegs, G., Uhlig, S., Weitzel, F., and Wendel, A.
Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-*J. Immunol. 149, 918-924, 1992

Wendel, A. Biochemical functions of selenium.Phosphorus, Sulfur, and Silicon 67, 405-415, 1992

Uhlig, S., and Wendel, A. The physiological consequences of glutathione variations
Life Sciences 51, 1083-1094, 1992

Wendel, A. "Selensupplementierung - wann ist sie sinnvoll?" Deutsche Apotheker Zeitung 44, 2381-2384, 1992

Hartung, T., Tiegs, G., and Wendel, A. "The role of leukotriene D4 in septic shock models"
Eicosanoids 5, 42-44, 1992

Hartung, T. and Wendel, A. "Endotoxin-inducible cytotoxicity in liver cell cultures - II: Demonstration of endotoxin-tolerance" Biochem. Pharmacol. 43, 191-196, 1992

Weitzel, F. and Wendel, A. "Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase
via the peroxide tone. "The Journal of Biological Chemistry 268, 6288-6292, 1993

Hartung, T. and Wendel, A."Entwicklung eines Zellkulturmodelles für das Organversagen im
septischen Schock" ATLA 18, 16-24, 1993

Fischer, W., Schudt, Ch. and Wendel, A."Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice".Biochem. Pharmacol. 45, 2399-2404, 1993

Wendel, A. "Selen in der Medizin"In: Selen in der Medizin (Beitrag von P. Oehme, W. Krause, E. Görres, N. Michael und O. Gomazkov, Berlin).Arzneimitteltherapie, S. 355-357, 1993

Tiegs, G., Barsig, J., Matiba, B., Uhlig, S. and Wendel, A.."Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice" J. Clin. Invest. 93, 2616-2622, 1994

Schewe, C., Schewe, T. and Wendel, A."Strong inhibition of mammalian lipoxygenase by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione". Biochem. Pharmacol. 48, 65-74, 1994

Uhlig, S., Wollin, L. and Wendel, A. "Contributions of thromboxane and leukotrienes to platelet-activating factor-induced impairment of lung function in the rat".J. Appl. Physiol. 77, 262-269, 1994

Leist, M., Gantner, F., Bohlinger, I., Germann, P.G., Tiegs, G. and Wendel, A. "Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-* requires transcriptional arrest". J. Immunol. 153, 1778-1787, 1994

Hartung, T., Sauer, A. and Wendel, A. "Immunopharmacological testing in-vitro". Cell Physiol. Biochem. 5, 62, 1995

Leist, M., Gantner, F., Jilg, S. and Wendel, A. "Activation of the 55 kDa TNF Receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release". J. Immunol. 154, 1307-1316, 1995

Leist, M. and Wendel A. "Tunikamycin potently inhibits tumor necrosis factor-induced hepatocyte
apoptosis" Eur. J. Pharmacol. 292, 201-204, 1995

Hartung, T., Döcke, W.-D., Gantner, F., Krieger, G., Sauer, A., Stevens, P., Volk H.-D., and Wendel, A. "Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers" Blood 85, 2482-2489, 1995

Leist, M., Gantner, F., Bohlinger, I., Tiegs, G., Germann P.G. and Wendel, A. "Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models".Am. J. Pathology 146, 1220-1234, 1995

Uhlig, S., Brasch, F., Wollin, L., Fehrenbach, H., Richter, J. and Wendel, A. "Functional and fine structural changes in isolated rat lungs challenged with endotoxin ex vivo and in vitro" Am. J. Pathology. 146, 1235-1247, 1995

Hartung, T. und Wendel, A. "Die Erfassung von Pyrogenen in einem humanen Vollblutmodell"
ALTEX 12, 70-75, 1995

Hartung, T., Volk, A. and Wendel, A.."G-CSF - an anti-inflammatory cytokine"J. Endotoxin Research 2, 195-201, 1995

Gantner, F., Leist, M., Jilg, S., Germann, P.G., Freudenberg, M.A. and Tiegs, G. "Tumor Necrosis Factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice". Gastroenterology 109, 166-176, 1995

Bohlinger, I. Leist, M., Barsig, J., Uhlig, S., Tiegs, G., and Wendel A. "Interleuking-1 and nitric oxide protect against tumor necrosis factor-*-induced liver injury through distinct pathways". Hepatology 22, 1829-1837, 1995

Bundschuh, D.S., Uhlig, S., Leist, M., Sauer, A. and Wendel, A."Isolation and characterization of rat primary lung cells" In Vitro Cell. Dev. Biol. 31, 684-691, 1995

Barsig, J., Küsters, S., Vogt, K., Volk, H.-D., Tiegs, G. and Wendel, A. "Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-* . Eur. J. Immunol. 25, 2888-2893, 1995

Uhlig, S., v. Bethmann, A.N., Featherstone, R. and Wendel A. "Pharmacologic characterization of endothelin receptor responses in the isolated perfused rat lung" Am. J. Respir. Crit. Care Med. 152,

Gantner, F., Uhlig, S. and Wendel, A. "Quinine inhibits release of tumor necrosis factor, apoptosis, necrosis and mortality in a murine model of septic failure". European J. Pharmacology 294, 353-355, 1995.

Bohlinger, I., Leist, M., Barsig, J., Uhlig, S., Tiegs, G. and Wendel A "Tolerance against tumor necrosis factor * (TNF)-induced hepatotoxicity in mice: the role of nitric oxide". Toxicology Letters 82/83, 227-231, 1995

Tenor, H., Stanciu, L., Schudt, C., Hatzelmann, A., Wendel, A., Djukanovic, R., Church, M. K. and Shute, J. K. "Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes". Clin and Exp Allergy 25, 616-624, 1995

Tenor, H., Hatzelmann, A., Kupferschmidt, R., Stanciu, L., Djukanovic, R., Schudt, C., Wendel, A., Church, M. K. and Shute, J. K. "Cyclic nucleotide phosphodiesterase isoenzyme activities in human
alveolar macrophages" .Clin and Exp Allergy 25, 625-633, 1995

Leist, M., Gantner, F., Künstle, G., Bohlinger, I., Blüthmann, H., Tiegs, G. and Wendel A.
"The 55-kD Tumor Necrosis Factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure". Molecular Medicine 2, 109-124, 1996

Hartung, T., Hermening, S., Sauer, A. and Wendel A. "Freisetzung eines Botenstoffes der Entzündung (TNF-*) aus Lebermakrophagen in Perfusions-Zellkultur". ALTEX 13, 17-24, 1996

Leist, M., Auer-Barth, S. and Wendel, A. "Tumor Necrosis Factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines". J Pharm Exp Ther 276, 968-976, 1996

Uhlig, S., Nüsing, R., v. Bethmann, A., Featherstone, R.L., Klein, T., Brasch, F., Müller, K.-D., Ullrich, V. and Wendel A. "Cyclooxygenase-2 dependent bronch-constriction in perfused rat lungs
exposed to endotoxin". Molecular Medicine 2, 373-383, 1996

Jilg, S., Barsig, J., Leist. M., Küsters, S., Volk, H.-D. and Wendel, A. "Enhanced release of Interleukin-10 and soluble Tumor Necrosis Factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock". J Pharm Exp Ther 278, 421-431, 1996

Bundschuh, D., Uhlig, S. and Wendel, A."Isolation of rat primary lung cells: characterization of an improved method". Exp Toxic Pathol 48, 512-514, 1996

Uhlig, S., Featherstone, R.L., Wilhelms, O.-H. and Wendel, A. "Effect of urodilatin on platelet-activating factor-induced bronchoconstriction, vasoconstriction and edema formation
in isolated rat lung". Naunyn-Schmiedeberg's Arch Pharmacol 354,1-5 ,1996

Bohlinger, I., Leist, M., Gantner, F., Angermüller, S., Tiegs, G. and Wendel A."DNA fragmentation in mouse organs during endotoxin shock" Am J Pathol 149, 1381-1393, 1996

Barsig, J., Bundschuh., D.S., Hartung, T., Bauhofer, A., Sauer, A. and Wendel, A. "Control of fecal peritoneal infection in mice by colony-stimulating factors" J Infect Diseases 174, 790-799, 1996

Sauer, A., Hartung, T., Aigner, J. and Wendel A. "Endotoxin-inducible granulotcyte-mediated hepatocytotoxicity requires adhesion and serine protease release" J Leukocyte Biol 60, 633-643, 1996

Leist, M. and Wendel, A. "A novel mechanism of murine hepatocyte death inducible by
Concanavalin A". J Hepatology 25, 948-959, 1996

Hartung, T. and Wendel, A. "Detection of pyrogens using human whole blood". In vitro Toxicology 9, 353-359, 1996

v. Bethmann, A.N., Brasch, S., Müller, K., Wendel, A. and Uhlig, S. "Prolonged hyperventilation is required for release of tumor necrosis factor * but not IL-6". Applied Cardiopulmonary Pathophysiology 6, 171-177 1996

Gantner, F., Küsters, S., Wendel, A., Hatzelmann, A., Schudt, C. and Tiegs, G. "Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors". J Pharmacol Exp Ther 280, 53-60, 1997

Leist, M., Gantner, F., Naumann, H., Bluethmann, H., Vogt, K., Brigelius-Flohé R., Nicotera, P. L., Volk H.-D. and Wendel, A."Tumor Necrosis Factor-induced apoptosis during poisoning of mice with
hepatotoxins".Gastroenterology 112, 924-935, 1997

Held, H.-D., Wendel, A., and Uhlig S. "Phosphodiesterase inhibitors prevent endothelin-1-induced
vasoconstriction, brochoconstriction, and thromboxane release inperfused rat lung". Biochem Biophys Res Comm 231, 22-25 1997

Künstle, G., Leist, M., Uhlig, S., Revesz, L. Feifel, A., MacKenzie, A and Wendel, A. "ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-*"
Immunol Lett 55, 5-10, 1997

Hartung, T., Sauer, A., Hermann, C., Brockhaus, F. and Wendel, A."Overactivation of the immune system by translocated bacteria and bacterial products".Scand J Gastroenterol 32, Suppl. 222, 98-99, 1997

Bundschuh, D.S., Barsig, J., Hartung, T., Randow, F. Döcke, W.-D., Volk, H.-D, and Wendel, A.
"Granulocyte-Macrophage Colony-Stimulating Factor and IFB-* restore the systemic TNF-* response to endotoxin in lipopolysaccharide-desensitized mice". J Immunology 158, 2862-2871, 1997

Randow, F., Döcke, W.-D., Bundschuh, D.S., Hartung, T., Wendel, A and Volk, H.D."In vitro prevention and reversal of lipopolysaccharide desensitization by IFN-*, IL-12, and granulocyte-macrophage colony-stimulating factor". J Immunology 158, 2911-2918, 1997

Gantner, F., Kupferschmidt, R., Schudt, Ch., Wendel, A., and Hatzelmann A.."In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor-* release by PDE inhibitors". British Journal of Pharmacology 121, 221-231, 1997

Küsters, S., Tiegs, G., Alexopoulou, L., Pasparakis, M., Douni, E., Künstle, G., Bluethmann, H., Wendel, A., Pfizenmeier, K., Kollias, G. and Grell, M. "In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis". Eur J Immunol 27, 2870-2875, 1997

Gantner, F., Tenor, H., Gekeler, V., Schudt, Ch., Wendel, A. and Hatzelmann, A. "Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study". J Allergy Clin Immunol 100, 527-535, 1997

Leist, M., Künstle, G., Gantner, F. and Wendel, A. "Receptor-mediated experimental hepatic apoptosis" In: Autoimmune Liver Disease, International Falk Workshop (P. Berg, AW Lohse, G. Tiegs, A. Wendel, eds.) Kluwer Academic Publishers, Dordrecht, pp 13-31, 1997

Uhlig, S., Featherstone, R. L.Held, H.-D., Nüsing, R., Schudt, C. and Wendel, A., "Attenuation by phosphodiesterase inhibitors of lipopolysaccharide-induced thromboxane release and bronchoconstriction in rat lungs". J Pharmacol Exp Ther 283, 1453-1459, 1997

Biesalski, H. K., Berger, M. M., Brätter, P., Brigelius-Flohé, R., Fürst, P.,Köhrle, J., Oster, O., Shenkin, A., Viell, B. und Wendel, A. "Kenntnisstand Selen - Ergebnisse des Hohenheimer Konsensusmeetings" Akt. Ernähr.-Med. 22, 224-231, 1997

Leist, M., Single, B., Künstle, G., Volbracht, C., Hentze, H. and Nicotera, P.,“Apoptosis in the absence of poly-(ADP-ribose) polymerase“. Biochem Biophys Res Commun 17, 518-522, 1997

Gantner, F., Götz, C., Gekeler, V., Schudt, C., Wendel, A. and Hatzelmann, A. "Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation". Br J Pharmacol 123, 1031-1038, 1998

Weisser, M., Tiegs, G., Wendel, A. and Uhlig, S. "Quantification of apoptotic and lytic cell death by video microscopy in combination with artificial neural networks". Cytometry 31, 20-28, 1998

von Bethmann, A. N., Brasch, F., Nüsing, R., Vogt, K., Volk, H. D., Müller, K-M., Wendel, A. and Uhlig, S."Hyperventilation induces release of cytokines from perfused mouse lung". Am J Respir Crit Care Med 157, 263-272, 1998

Leist, M., Gantner, E., Künstle, G., and Wendel A. "Cytokine-mediated hepatic apoptosis".
Rev Physiol Biochem Pharmacol 133, 109-155, 1998

Hartung, T. and Wendel, A. "Immunomodulatory properties of Filgrastim (r-metHuG-CSF) in
preclinical models" In: Filgrastim (r-metHuG-CSF) in Clinical Practice (Morstyn, Dexter,
Foote, eds.) M. Dekker, New York, pp. 397-427, 1998

Fehrenbach, H., Brasch, F., Uhlig, S., Weisser, M., Stamme, C., Wendel, A. and Richter, J. "Early alterations in intracellular and alveolar surfactant of the rat lung in response to endotoxin". Am J Respir Crit Care Med 157, 1630-1639, 1998

Hartung, T., Pitrak, D.L., Foote, M.A., Shatzen, E.M., Verral, S.C. and Wendel, A.
"Filgrastim Restores Interleukin-2 Production in Blood from Patients with Advanced Human Immunodeficiency Virus Infection", J Infect Dis 178, 686-692, 1998

Fennrich, S., Fischer, M., Hartung, T., Lexa, P., Montag-Lessing, T., Sonntag, H.-G., Weigandt, M. and Wendel, A.."Entwicklung und Evaluierung eines Pyrogentests mit menschlichem Blut"
ALTEX 15/3, 123-128, 1998

Tiegs, G., Küsters, S., Künstle, G., Hentze, H., Kiemer, A.K. and Wendel, A. "Ebselen Protects Mice Against T Cell-Dependent, TNF-Mediated Apoptotic Liver Injury". J Pharmacol Exp Ther, 287, 1098-1104, 1998

Hentze, H., Künstle, G., Volbracht, C., Ertel, W. and Wendel, A.“CD95-Mediated murine hepatic apoptosis requires an intact glutathione status“. Hepatology 30, 177-185, 1999

Stamme, C., Bundschuh, D.S., Hartung, T., Gebert, U., Wollin, L., Nüsing, R., Wendel, A. and Uhlig, S. “Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice“. Infect Immun 67, 5642-50, 1999

Künstle, G., Hentze, H., Germann, P.-G., Tiegs, G., Meergans, T. and Wendel, A. “Concanavalin A Hepatotoxicity in Mice: Tumor Necrosis Factor-Mediated Organ Failure Independent of Caspase-3-Like Protease Activation“. Hepatology 30, 1241-1251, 1999

Fennrich, S., Wendel, A. and Hartung, T. “New Applications of the Human Whole Blood Pyrogen Assay (PyroCheck)“. ALTEX 16/3, 146-149, 1999

“Characterisation of the Phophodiesterase (PDE) Pattern of In Vitro Generated Human Dendritic Cells (DC) and the Influence of PDE Inhibitors on DC Function“. Pulm Pharmacol Ther 12, 377-86, 1999

Kühnle, S., Nicotera, P., Wendel, A. and Leist, M. “Prevention of Endotoxin-Induced Lethality, but Not of Liver Apoptosis in Poly(ADP-ribose) Polymerase-Deficient Mice”. Biochem Biophys Res Commun 263, 433-38, 1999

Fennrich, S., Fischer, M., Hartung, T., Lexa, P., Montag-Lessing, T., Sonntag, H.-G., Weigandt, M. and Wendel, A. “Detection of Endotoxins and other Pyrogens Using Human Whole Blood”. Dev Biol Stand 101, 131-39, 1999

Falk, S., Göggel, R., Heydasch, U., Brasch, F., Müller, K.-M., Wendel, A. and Uhlig, S. “Quinolines Attenuate PAF-induced Pulmonary Pressor Responses and Edema Formation”. Am J Respir Crit Care Med 160, 1734-42, 1999

Hartung, T., Doecke, W.-D., Bundschuh, D., Foote, M.A., Gantner, F., Hermann, C.,Lenz, A., Milwee, S., Rich, B., Simon, B., Volk, H.-D., von Aulock, S. and Wendel, A.“Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions”. Clin Pharm Ther 66, 415-24, 1999

Boneberg, E.M., Hareng, L., Gantner, F., Wendel, A. and Hartung, T. “Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-?”. Blood 95, 270-76, 2000

Hentze, H., Gantner, F., Kolb, S.A. and Wendel, A.“Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice“. Am J Pathol 156, 2045-2056, 2000

Latta, M., Künstle, G., Leist, M. and Wendel, A. “Metabolic depletion of adenosine triphosphate by fructose inversely controls CD95- and TNF-R1-mediated hepatic apoptosis“ J Exp Med 191, 1975-1985, 2000

Meergans, T., Hildebrandt, A.-K., Horak, D., Haenisch, Chr. and Wendel, A. "The short prodomain influences caspase-3 activation in HeLa cells". Biochem J 349, 135-140, 2000

Hartung, T., von Aulock, S. and Wendel, A.
"Growth Factors G-CSF and GM-CSF: Clinical Options"
In: Multiple Organ Failure (A.E. Baue, E. Faist, D.E. Fry, eds.), Springer New York,
pp. 621-629, 2000

Hartung, T., von Aulock, S., Freitag, M., Höxtermann, S., Stücker, M., Hoffmann, K., Altmeyer, P., Kottke, A. und Wendel, A."Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients". Cytokine, 12, 1570-1574, 2000

Lehner, M. D., Ittner, J., Bundschuh, D. S., van Rooijen, N., Wendel, A., and Hartung, T. "Improved Innate Immunity of Endotoxin-Tolerant Mice Increases Resistance to Salmonella enterica Serovar Typhimurium Infection despite Attenuated Cytokine Response". Infect. Immun. 69, 463-471, 2001

Diterich, I., Härter, L., Hassler, D., Wendel, A., and Hartung, T. "Modulation of Cytokine Release in Ex Vivo-Stimulated Blood from Borreliosis Patients". Infect. Immun. 69, 687-694, 2001

Wollin, L., Uhlig, S., Nüsing, R., and Wendel, A.. "Granulocyte-macrophage colony-stimulating factor amplifies lipopolysaccharide-induced bronchoconstriction by a neutrophil- and cyclooxygenase 2-dependent mechanism". Am J Respir Crit Care Med 163, 443-450, 2001

Eichert, K., Hamacher, J., Wunder, M.A., and Wendel, A. "Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via Endothelin". J Pharmacol Exp Ther 297, 128-132, 2001

Hentze, H., Schwoebel, F., Lund, S., Kehl, M., Ertel, W., Wendel, A., Jäättelä, M., Leist, M.
"In Vivo and in Vitro Evidence for Extracellular Caspase Activity Released from Apoptotic Cells"
Biochem Biophys Res Commun 283, 1111-1117, 2001


Hentze, H., Schmitz, I., Latta, M., Krueger, A., Krammer, P.H., and Wendel, A. "Glutathione Dependence of Caspase-8 Activation at the Death-inducing Signaling Complex". J Biol Chem 277, 5588-5595, 2002

Wendel, A. "Do we need a 'Chair of Alternative Methods', and where?" ALTEX 19, 64-68, 2002

Hamacher, J., Lucas, R., Lijnen, H.R., Buschke, S., Dunant, Y., Wendel, A., Grau, G.E., Suter, P.M., and Ricou, B. "Tumor Necrosis Factor-? and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome". Am J Respir Crit Care Med 166, 651-656, 2002

Lucas, R., Grau, G.E., Matthay, M.A., and Wendel, A. "Functional dissection of Tumor Necrosis Factor in liver, brain and lungs" Current Trends in Immunology 4, 47-59, 2002

Hentze, H., Latta, M., Künstle, G., Lucas, R., and Wendel, A. "Redox control of hepatic cell death"
Toxicology Letters 139, 111-118, 2003

Xu, J., Lucas, R., Schuchmann, M., Kühnle, S., Meergans, T., Barreiros, A. P.,
Lohse, A. W., Otto, G., and Wendel, A. "GM-CSF restores innate, but not adaptive, immune responses in glucocorticoid-immunosuppressed human blood in vitro". J. Immunol. 171, 938-947, 2003

Lucas, R., Xu, J., Braun, C., Leja, A., Meergans, T., Hamacher, J., and Wendel, A. "Tumor necrosis factor in bacterial and protozoan infections: To be or not to be?" Recent Res. Devel. Infection & Immunity 1, 303-316, 2003

Safir, N., Wendel, A., Saile, R., and Chabraoui, L. "The Effect of Selenium on Immune Functions of J774.1 Cells". Clin Chem Lab Med 41 (8), 1005-1011, 2003

Husain, B., Lendemans, S., Ackermann, M., Wendel, A., Schade, F.U., and Flohé, S. "GM-CSF counteracts hemorrhage-induced suppression of cytokine-producing capacity". Inflamm. Res. 53, 13-21, 2004

Hentze, H., Latta, M., Künstle, G., Dhakshinamoorthy, S., Yong Ng, P., Porter, A.G., and Wendel, A.
"Topoisomerase inhibitor Camptothecin sensitizes mouse hepatocytes in vitro and in vivo to TNF-mediated apoptosis". Hepatology 39, 1311-1320, 2004

Xu, J., Lucas, R., and Wendel, A. "The potential of GM-CSF to improve resistance against infections in organ transplantation". Trends in Pharmacological Sciences 25, 254-258, 2004

Wendel, A., Xu, J. und Lucas, R. "GM-CSF: Eine mögliche Lösung des Dilemmas zwischen Infektion und Abstoßung nach Transplantation" in: BIOspektrum, 522-524, 2004

Weiller, M., Latta, M., Kresse, M., Lucas, R., Wendel, A. "Toxicity of nutritionally available selenium compounds in primary and transformed hepatocytes". Toxicology 201, 21-30, 2004

Schindler, St., Asmus, S., von Aulock, S., Wendel, A., Hartung, T., Fennrich, St. “Cryopreservation of human whole blood for pyrogenicity testing“. J. of Immunol Methods 294, 89-100, 2004

Xu, J., von Aulock, S., Lucas, R., Wendel, A. “Potential of colony-stimulating factors to improve host defense in organ transplant recipients“. Curr Opin Organ Transpl 9, 411-417, 2004

Hoffmann, S., Peterbauer, A., Schindler, S., Fennrich, St., Poole, St., Mistry, Y., Montag-Lessing, T., Spreitzer, I., Löschner, B., van Aalderen, M., Bos, R., Gommer, M., Nibbeling, R., Werner-Felmayer, G., Loitzl, P., Jungi, T., Brcic, M., Brügger, P., Frey, E., Bowe, G., Casado, J., Coecke, S., de Lange, J., Mogster, B., Naess, L.M., Aaberge, I.S., Wendel, A., Hartung, T. ”International validation of novel pyrogen tests based on human monocytoid cells” J. Immunol. Methods 298, 161-173, 2005

Schwoebel, F., Barsig, J., Wendel, A., Hamacher, J. “Quantitative assessment of mouse skin transplant rejection using digital photography“. Laboratory Animals 39, 209-214, 2005


Kresse, M., Latta, M., Künstle, G., Riehle, H.-M., van Rooijen, N., Hentze, H., Tiegs, G., Biburger, M., Lucas, R., Wendel, A. “Kupffer Cell Expresses Membrane-Bound TNF and Mediates Melphalan Hepatotoxicity via Activation of Both TNF Receptors”. J Immunology 175, 4076-4083, 2005

Braun, C., Hamacher, J., Morel, D.R., Wendel, A., Lucas, R. “Dichotomal Role of TNF in Experimental Pulmonary Edema Reabsorption“. J Immunology 175, 3402-3408, 2005

Lucas, R., Kresse, M., Latta, M., Wendel, A. ”Tumor Necrosis Factor: How to Make a Killer Molecule Tumor-Specific?” Current Cancer Drug Targets 5, 381-392, 2005

Daneshian, M., Guenther, A., Wendel, A., Hartung, T., von Aulock, S., ”In vitro pyrogen test for toxic or immunomodulatory drugs”, J. Immun. Methods 313, 169-175, 2006


Hermann C, von Aulock S, Dehus O, Keller M, Okigami H, Gantner F, Wendel A, Hartung T. Endogenous cortisol determines the circadian rhythm of lipopolysaccharide-- but not lipoteichoic acid--inducible cytokine release. Eur J Immunol. 36, 371-379, 2006

Clemedson C, Blaauboer B, Castell J, Prieto P, Risteli L, Vericat JA, Wendel A. ACuteTox - Optimation and Pre-validation of an In Vitro Test Strategy for Predicting Human Acute Toxicity.ALTEX. 23, 254-25 8, 2006

Latta M, Künstle G, Lucas R, Hentze H, Wendel A. ATP-depleting carbohydrates prevent tumor necrosis factor receptor 1-dependent apoptotic and necrotic liver injury in mice. J Pharmacol Exp Ther.321, 875-83, 2007

Kähler CM, Wechselberger J, Hilbe W, Gschwendtner A, Colleselli D, Niederegger H, Boneberg EM, Spizzo G, Wendel A, Gunsilius E, Patsch JR, Hamacher J. Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res. 2007, 8, 50-54.
Dünstl G, Weiland T, Schlaeger C, Nüssler A, Künstle G, Wendel A. Activation of an alternative death receptor-induced signaling pathway in human hepatocytes under caspase arrest. Arch Biochem Biophys. 462, 140-9, 2007

Mazzotti F, Beuttler J, Zeller R, Fink U, Schindler S, Wendel A, Hartung T, von Aulock S. In vitro pyrogen test--A new test method for solid medical devices. J Biomed Mater Res A. 2007;80:276-82
Hamacher J, Eichert K, Braun C, Grebe T, Strub A, Lucas R, Eltze M, Wendel A. Montelukast exerts no acute direct effect on NO synthases. Pulm Pharmacol Ther.5, 525-33, 2007

Daneshian M, Wendel A, Hartung T, von Aulock S. High sensitivity pyrogen testing in water and dialysis solutions. J Immunol Methods 336: 64-70, 2008

R. Kreiling, H.M. Hollnagel , L. Hareng, D. Eigler, M.S. Lee , P. Griem, B. Dreeßen ,M. Kleber , A. Albrecht, C. Garcia and A. Wendel : Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA)and the guinea pig maximization test (GPMT). Food and Chemical Toxicology 46, 1896–1904, 2008

Bunk S, Susnea I, Rupp J, Summersgill JT, Maass M, Stegmann W, Schrattenholz A, Wendel A, Przybylski M, Hermann C. Immunoproteomic identification and serological responses to novel Chlamydia pneumoniae antigens that are associated with persistent C. pneumoniae infections. J Immunol. 180, 5490-98, 2008

Hundsberger H, Verin A, Wiesner C, Pflüger M, Dulebo A, Schütt W, Lasters I, Männel DN, Wendel A, Lucas R. TNF: a moonlighting protein at the interface between cancer and infection. Front. Biosci.13, 5374-86, 2008

Hamacher J, Lucas R, Stammberger U, Wendel A. Terbutaline improves ischemia-reperfusion injury after left-sided orthotopic rat lung transplantation. Exp Lung Res., 35:175-85, 2009
Hamacher J, Stammberger U, Weber E, Lucas R, Wendel A. Ebselen improves ischemia-reperfusion injury after rat lung transplantation. Lung 187, 98-103, 2009

Weiland T, Weiller M, Künstle G, Wendel A. Sensitization by 5-azacytidine toward death receptor-induced hepatic apoptosis. J Pharmacol Exp Ther. 328:107-15, 2009.

Speicher, T., Foehrenbacher, A., Pochic, I., Weiland, T. and Wendel, A. „Malignant but not naïve hepatocytes of human and rodent origin are killed by TNF after metabolic depletion of ATP by fructose”, submitted Hepatology, 2010

Speicher, T. Köhler, U., Chouker, A., Weiland, T. and Wendel, A.m “Fructose-induced ATP depletion in murine hepatocytes protects from TNF-induced apoptosis by inhibition of JNK signaling”
submitted Hepatology, 2010

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